NIOD Copper Amino Isolate Serum Review

23rd September 2019 in Hall of Fame, Serum, Skincare - 5 Comments - Talia James (The Skincare Saviour) - 4 min read
NIOD Copper Amino Isolate Serum Review

Welcome, Skintellectuals!

I get excited when I see new and innovative products. It’s so rare to see something different and new so you can understand why I love the brand NIOD so much. The people at NIOD are innovators, all their products are based in science and have testable results which to me is how all skincare should be.

NIOD Copper Amino Isolate Serum Review

What is it?

Copper Amino Isolate Serum is a peptide serum that is all about maintaining skin health, this pro-repair, pro-collagen serum offers a novel approach to target all signs of skin ageing indirectly. This indirect approach departs from the traditional thinking of addressing visible aspects of skin ageing individually and instead forms a foundation to respect skin health. Think of it as a serum to treat everything from the inside outward instead of trying to alter the skin on a surface level.

NIOD Copper Amino Isolate Serum Review

What does it do?

Copper peptides can found in trace amounts in blood plasma, saliva and urine and are fantastic healers this means that they can rejuvenate skin cells in tissue by boosting the production of elastin and collagen. As with age, these naturally occurring proteins decrease but by increasing the amount in the skin with serums and treatments containing copper peptides we can regain some of this elasticity.

Whilst copper peptides are a great way to stave off the wrinkles and fine lines, I love them for their healing properties! I’ve found that I tend to get less scarring from post-acne marks and the ones that do end up scarring are gone in half the time I would usually take.

NIOD Copper Amino Isolate Serum Review

How do you use it?

You can use CAIS twice a day in both the AM and PM and it is usually applied after cleansing as you want it to be able to penetrate as best as possible. There is advice on the NIOD website to not use any direct acids in the same routine as CAIS as the acids will end up neutralising the copper peptide. I tend to still use acids but I will apply CAIS first wait for about 10/15 before I apply an acid on top to make sure its sunk it and absorbed before moving on. I find that CAIS works the same and I get the same results when I don’t use an acid but it’s up to you if you want to break the rules/advice.

I would also advise against using copper peptides and vitamin c together, you use a vitamin c in the morning then try to use CAIS in the evening. When used together the copper oxidizes the ascorbic acid (vitamin c) and causes it to break down rapidly so you won’t get the benefit of the vitamin c and you’ll be left with a lovely bright orange face, fortunately, you can wash it off but it will stain your nails if you get any of them.

What’s in it?

*Aqua (Water) solv, *Copper Gluconate so, *Isoceteth-20 emu|surf, *Phenoxyethanol pres, *Chlorphenesin pres|amic, **Aqua (Water) solv, **Glycerin sii|h 0 0, **Tripeptide-29 cci, **Tripeptide-1 cci, **Myristoyl Nonapeptide-3 cci, **Trifluoroacetyl Tripeptide-2 cci, **Acetyl Tetrapeptide-2 cci, **Sodium Hyaluronate Crosspolymer sii|aox|h, **Glycogen h, **Propanediol solv|h, **Pentylene Glycol solv|h, **Dextran vc, **Dimethyl Isosorbide solv, **Ethoxydiglycol solv 0 0, **Isoceteth-20 emu|surf, **Leuconostoc/Radish Root Ferment Filtrate amic|pres, **Caprylyl Glycol h|emo, **Ethylhexylglycerin pres, **Phenoxyethanol pres, **Chlorphenesin pres|amic
*Copper Concentrate, **Activator
Hover the mouse / tap over an ingredient for short explanation. Read more on INCIDecoder.

When will I see results?

If you’re looking for quick results then this isn’t the product for you. While the website does say it can take up to 5 days of daily use to notice anything, I feel like that is a massive understatement while yes my skin did feel and look good after a week of using CAIS it wasn’t until about 3/4 months into using it daily did I see any real difference and i only noticed a difference because I ran out and noticed how my skin was when I wasn’t using CAIS.
If you don’t want to wait for the results then this isn’t the product for you but if you stick it out the results are worth the wait.

NIOD Copper Amino Isolate Serum Review

Closing Thoughts

Personally I love CAIS, I’ve had so many fantastic results while using. I tend to break out less and when I do break out it isn’t the normal big red angry papules/pustules. I find that I get less pigmentation from acne marks as well which is a big thing for me because my skin gains pigmentation like nobodies business.

You can find NIOD Copper Amino Isolate Serum in 15ml (£38) and 30 ml (£60*) available online at as well as in stand-alone stores and counters.

Have you used CAIS before?
What do you think about copper peptides?
Leave a Comment!

Talia James (The Skincare Saviour)

Scottish science nerd obsessed with all things beauty! Creator of The Skincare Saviour, a skincare blog covering everything from reviews, tutorials to busting myths, finding dupes and breaking down trends.

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  • Angela 23rd September 2019 at 7:12 pm

    I’ve been looking to grab this one once I get through my large skin care stash – sounds like the results could be worth the wait.

    Angela |

  • Shireen 24th September 2019 at 7:32 am

    I am cheap so I use The Ordinary Copper and Pptide serum. Don’t really see any results from it but I use it more as a preventative measure.

  • Shaun 6th December 2019 at 7:51 pm

    Do you know if CAIS can be used in the same routine as Tretinoin? I am also wondering about SDSM-2, as it is a strong antioxidant, which is apparently compromised by the copper peptides. Thanks!

    • The Skincare Saviour 29th December 2019 at 8:31 pm

      Hi there! i use CAIS in my routine with Adapalene so im sure it will be fine, i usually find it helps as copper peptides aid in healing so i tend not to get so irritated or peely

  • Samah Al-haj 1st May 2020 at 3:03 pm

    Want to know if I can you NIOD Copper with Retinoid?

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    Welcome to fellow skintellectuals to The Skincare Saviour, a skincare blog covering everything from reviews, tutorials to busting myths, finding dupes and breaking down trends. All posts marked * have been sent to The Skincare Savior for consideration for review. All opinions on these products are my own. Read More


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